Handling Guide

FLEXcyte iCELL Handling Guide v221012
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Service Flyers

AtlaZ Service Flyer v230620
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FLEXcyte CardioExcyte Combined Service Flyer v230206
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FLEXcyte 96 Cardiac Safety and Toxicity Service Flyer v211108
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FLEXcyte Contractile Force Flyer v210911
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FLEXcyte Stimulation Flyer v230124
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AppNotes

FLEXcyte 96 Recordings Compared to Musclemotion Data
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FLEXcyte 96 Pro-Maturation Effect on HiPSC-Derived Cardiomyocytes
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Robustness Study of iCell Lots Performed With FLEXcyte 96
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Chronic Cardiotoxic Effects of TKIs and Anthracyclines Analyzed with the FLEXcyte 96
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Measuring Cardiac Contractility of iCells with the FLEXcyte 96 System
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Contractility Analysis of axoCells iPSC-Derived Atrial and Ventricular Cardiomyocytes Assessed on the FLEXcyte 96
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Evaluating iCell Cardiomyocytes2 in Co-Culture with iCell Cardiac Fibroblasts on the FLEXcyte 96 System
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Publications

Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development

2024, Journal of Pharmacological and Toxicological Methods

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of HiPSC-CMs for Preclinical Cardiac Risk Evaluation

2022, Journal of Visualized Experiments

Integration of Mechanical Conditioning Into a High Throughput Contractility Assay for Cardiac Safety Assessment

2020, Journal of Pharmacological and Toxicological Methods

Higher Throughput In Vitro Cardiac Contractility Recordings under Physiological Mechanical Conditions

2019, FLEXcyte White Paper

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Mechano-Pharmacological Characterization of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells

2016, Cellular Physiology and Biochemistry

Posters

In Vitro Systems for the Assessment of Chronic Cardiotoxic Effects: News from the HESI Stem Cell Working Group

2024, Society of Toxicology Annual Meeting, Salt Lake City, USA

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Contractility-Based Pharmacological Characterization of HiPSC-Atrial and Ventricular Cardiomyocytes Assessed on the FLEXcyte 96

2023, Safety Pharmacology Society Annual Meeting, Brussels, Belgium

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NAM-Related Robustness Analysis of Commercial hiPSC-Cardiomyocytes in the Light of Preclinical Cardiac Risk Assessment

2023, Society of Toxicology Annual Meeting, Nashville, USA

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Assessment of a Smooth Muscle Cell Maturation Protocol for the Analysis of Contractile Properties

2022, Safety Pharmacology Annual Meeting, Montréal, USA

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Lot-to-Lot Consistency Study of Commercial Human iPSC- Derived Cardiomyocytes Regarding Contractile Properties

2022, Safety Pharmacology Annual Meeting, Montréal, USA

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Tackling Chronic Compound Responses of hiPSC-CMs for Preclinical Cardiac Risk Evaluation

2022, Biophysical Society Annual Meeting, SanFransisco, USA

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How The Environment Alters Gene Expression, Phenotype and Functional Properties of HiPSC-CMs

2021, Safety Pharmacology Society Annual Meeting, Virtual Event

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Defined Serum-Free Medium and Long-Term Culture on the FLEXcyte 96

2021, Nanion User Meeting, Munich, Germany

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High Throughput Chronic Cardiotoxicity Evaluation of Human iPSC-Derived Cardiomyocytes in a Pro-Maturation Environment

2021, Eurotox Annual Meeting, Virtual Event

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Chronic Cardiac Contractility Assessment of Human iPSC-Derived Cardiomyocytes in a Pro-Maturation Environment

2021, 11th World Congress on Alternatives and Animal Use in Life Sciences, Virtual Event

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A Physiological Environment for Human iPSC-Derived Cardiomyocytes Facilitates Maturation for Reliable Preclinical Risk Evaluation

2021, EUROoCS Annual Meeting, Virtual Event

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Chronic Cardiotoxic Effects of Kinase Inhibitors and Anthracyclines on Human iPSC-Derived Cardiomyocytes

2021, Society of Toxicology Annual Meeting, Virtual Event

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Mechanical Stimulation in a 2D High-Throughput Contractility System

2021, Society of Toxicology Annual Meeting, Virtual Event

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Artificial Neural Networks in Cardiac Safety Assessment

2020, Safety Pharmacology Society Annual Meeting, Virtual Event

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A Higher-Throughput Approach to Investigate Cardiac Contractility In Vitro Under Physiological Mechanical Conditions

2019, Safety Pharmacology Annual Meeting, Barcelona, Spain

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Videos

FLEXcyte 96 Membranes with Adherent Human iPSC-Derived Cardiomyocytes
FLEXcyte 96 – Investigate In Vitro Cardiac Contractility under Physiological Conditions
FLEXcyte 96 – Contraction Force Analysis
Nanion User Meeting (NUM) 2023
Cardiac Safety Meeting 2023
BSC Annual Meeting 2022
Cardiac Safety Meeting 2021