Meet us at the 3rd Microphysiological Systems World Summit (MPS) in Seattle, USA
Visit our booth at the 3rd MPS World Summit taking place in the Seattle Convention Center, from June 10th to 14th, 2024. Stay tuned for more information regarding posters and presentations.
Meet us at the Society of Toxicology in Salt Lake City, USA
Get ready to meet us at the 63rd SOT Annual Meeting & ToxExpo in Salt Lake City, March 10-14th, 2024. Stop by our booth 1832 to learn about our cell-based assay services!
Meeting with Ärzte gegen Tierversuche
We had a great time welcoming Tamara Zietek from Ärzte gegen Tierversuche e.V. at our headquarter in Jülich to show her innoVitro’s CRO service laboratories and technologies and to discuss new approach methodologies as a valid replacement for animal models.
Meet us at the Nanion User Meeting
The Nanion User Meeting will be held October 24 – 25 in Munich, Germany.
Meet us at the Safety Pharmacology Society Annual Meeting
The Safety Pharmacology Society (SPS) meeting will be held Septemeber 18 – 21 at the SQUARE Brussels Meeting Centre in Belgium. Stop by our booth No. 505 as well as poster and oral presentations
Cardiac Safety Committee Recognition Award 2022 -2023
We are happy to announce innoVitro’s CTO Peter Linder has been awarded the HESI Cardiac Safety Committee Recognition Award 2022 – 2023 for his exceptional contributions to the Stem Cell Working Group.
Meet us at the 2nd Microphysiological System World Summit in Berlin, Germany!
The MPS conference will take place June 26 – 30, 2023 in the JW Marriott Hotel Berlin. Click here for more information https://mpsworldsummit.com/ and keep an eye out news coming soon!
innoVitro awarded as most innovative in vitro technology company in Germany
innoVitro has been recognized by GHP (Global Health & Pharma) as most innovative in vitro technology company in Germany for the year 2022.
Meet us at the 62nd Society of Toxicology Annual Meeting in Nashville, USA
The SOT conference will take place in March 19 – 23, 2023. Keep an eye out for more information coming soon!
Meet us at the XVIth International Congress of Toxicology (ICT), September 18 – 21, 2022 in Maastricht, Netherlands
Meet us at the innoVitro Booth 51 in Maastrichts Expositie en Congres Centrum (MECC), September 18th – 21st, 2022.
We will also present a poster (No 456) entitelt „Chronic Compound Analysis of hiPSC-CMs in a Physiological Environment for Preclinical Cardiac Risk Evaluation: Defined Serum-Free Medium and Long-Term Culture on the FLEXcyte 96“.
We are looking forward to seeing you at the conference!
Safety Pharmacology Society Annual Meeting, September 11 -14, 2022 in Montréal, Canada
Meet us at the innoVitro Booth 810 in Montréal, Canada at the Safety Pharmacology Society Annual Meeting in September 2022!
Don’t miss our poster presentations entitelt (SP090) „Lot-to-lot consistency study of commercial human iPSC derived cardiomyocytes regarding contractile properties“ and (SP091) „Assessment of a Smooth Muscle Cell Maturation Protocol for the Analysis of Contractile Properties“.
We are looking forward to seeing you at the SPS 2022!
innoVation Facts – Cardiac Maturation Cues (Part 3)
The last part of our innoVation Facts series dealing with cardiac maturation cues focused on gene expression analysis of human iPSC-derived cardiomyocytes (hiPSC-CMs) cultured either on physiological FLEXcyte or regular cell culture plates.
The data shows increased expression levels of ACTC1 and ACTN2 genes (both producing cytoskeleton-related proteins) as well as the MYH7 gene (important for cardiac contraction) when hiPSC-CMs are plated on physiological FLEXcyte plates that resemble in vivo conditions of the human heart.
These changes in expression of genes relevant for contraction and cytoskeleton substantiate the phenotypic and functional changes of hiPSC-CMs shown in part 1 and 2 where mature actin structures and an increased contraction amplitude was shown.
innoVation Facts – Cardiac Maturation Cues (Part 2)
In our second part of the innoVation Facts series addressing cardiac maturation cues, we focus on phenotypic changes that take place when human iPSC-cardiomyocytes (hiPSC-CMs) are cultured on FLEXcyte 96 plates to emulate the physiological conditions of the human heart.
To visualize changes in actin filament development, staining with Phalloidin was performed on Cardiosight-s (Nexel Ltd.) hiPSC-CMs plated on FLEXcyte 96 plates for 7 days and 17 days. (Scale bars = 20µM)
The staining shows a clear change in actin development from fine structures at days 7 to more pronounced filaments including typical striation, indicating the establishment of sarcomers (Fritz-Six et al., 2003; Chu et al., 2003; Ehler et al., 2004).
innoVation Facts – Cardiac Maturation Cues (Part 1)
We are happy to announce our new innovation facts blog focussing on news about the FLEXcyte technology and related topics!
We start the blog with a series about cardiac maturation cues, a hot topic for everyone working on human iPSC-derived cardiomyocytes.
In this first part, we show you how to use the physiological environment of the FLEXcyte plate over time to push maturation in vitro.
What is your research focus? Get in contact to discuss your work, we are happy to support!