innoVation Series December 22 / January 23

With the New Year we are focussing on the importance of human iPSC-derived cardiomyocyte beat rate pacing for the analysis of drug effects. Hinata et al., 2022 investigated the relationship between contraction parameters and beating rates of cardiac cell sheet tissues by directly measuring the contraction force and compared the effects of ion channel drugs…Continue readinginnoVation Series December 22 / January 23

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Meet us at the 62nd Society of Toxicology Annual Meeting in Nashville, USA

The SOT conference will take place in March 19 – 23, 2023. Keep an eye out for more information coming soon!Continue readingMeet us at the 62nd Society of Toxicology Annual Meeting in Nashville, USA

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innoVation Series October / November 2022

The October issue of the innoVation series is a special workshop report of the FDA (Pang et al., 2019) on improving cardiotoxicity assessment with human-relevant platforms. In detail, the urgent need to integrate human-relevant platforms/approaches into drug development to reduce cardiovascular safety liabilities were discussed, including potential regulatory applications of human-derived cardiomyocytes and future directions…Continue readinginnoVation Series October / November 2022

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innoVitro awarded as most innovative in vitro technology company in Germany

innoVitro has been recognized by GHP (Global Health & Pharma) as most innovative in vitro technology company in Germany for the year 2022. Read the interview with Matthias Gossmann, CEO of innoVitro hereContinue readinginnoVitro awarded as most innovative in vitro technology company in Germany

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innoVation Series April – May 2022

The article from Chirikian et al., 2022 covering April and May of the innoVation Series addresses the effects of xeno-free cryopreservation on the contractile properties of human iPSC-derived cardiomyocytes. Read the article to find out about alterations in both the contractile and calcium handling properties of xeno-free cryopreserved hiPSC-CMs. Collectively, the authors observed increased force…Continue readinginnoVation Series April – May 2022

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Meet us at the XVIth International Congress of Toxicology (ICT), September 18 – 21, 2022 in Maastricht, Netherlands.

Meet us at the innoVitro Booth 51 in Maastrichts Expositie en Congres Centrum (MECC), September 18th – 21st, 2022. We will also present a poster (No 456) entitelt “Chronic Compound Analysis of hiPSC-CMs in a Physiological Environment for Preclinical Cardiac Risk Evaluation: Defined Serum-Free Medium and Long-Term Culture on the FLEXcyte 96”. We are looking…Continue readingMeet us at the XVIth International Congress of Toxicology (ICT), September 18 – 21, 2022 in Maastricht, Netherlands.

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Safety Pharmacology Society Annual Meeting, September 11 -14, 2022 in Montréal, Canada.

Meet us at the innoVitro Booth 810 in Montréal, Canada at the Safety Pharmacology Society Annual Meeting in September 2022! Don’t miss our poster presentations entitelt (SP090) “Lot-to-lot consistency study of commercial human iPSC derived cardiomyocytes regarding contractile properties” and (SP091) “Assessment of a Smooth Muscle Cell Maturation Protocol for the Analysis of Contractile Properties”.…Continue readingSafety Pharmacology Society Annual Meeting, September 11 -14, 2022 in Montréal, Canada.

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Society of Toxicology Annual Meeting, San Diego, CA, March 27-31, 2022

Check out our poster entitled “Tackling human iPSC-cardiomyocte maturation in vitro for predictive nonclinical cardio-toxicological assessment” at the SOT poster session in collaboration with Nanion Technologies!Continue readingSociety of Toxicology Annual Meeting, San Diego, CA, March 27-31, 2022

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innoVation Series – March 2022

In the March issue of the innovation Series a charcterization study of cardiac cells and their gene expression profiles was performed. Six anatomical adult heart regions were analyzed to establish a cardiac cell atlas for better understanding of the adult human heart. In detail, Litviňuková et al., 2022 highlight the cellular heterogeneity of cardiomyocytes, pericytes…Continue readinginnoVation Series – March 2022

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innoVation Series – February 2022

A newly published article assessing human induced pluripotent stem cell derived-cardiomyocyte (hiPSC-CM) contractility kinetics caught our interest this month. The data shows that flexible substrates are necessary for normal twitch-like contractility kinetics and interpretation of inotropic interventions. Huethorst et al. analyzed spatiotemporal contractility of hiPSC-CM monolayers seeded on conventional, rigid surfaces (glass or plastic) and…Continue readinginnoVation Series – February 2022

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