This month’s innovation series research article was published from our colleagues at the University of Cologne last week.
Find out how you can optimize cardiac differentiation out of human induced pluripotent stem cells. This biomimetic approach is based on poly(dimethylsiloxane) (PDMS) substrates with similar stiffness to the native heart and a well-defined surface chemistry obtained by conventional [(3-aminopropyl)triethoxysilane (APTES) and octadecyltrimethoxysilane (OTS)] and amino acid (histidine and leucine)-conjugated self-assembled monolayers (SAMs).
Spoiler alert: leucine-conjugated SAM modification provided the best environment for cardiac differentiation of iPSCs.
Find the article here https://pubs.acs.org/doi/10.1021/acsbiomaterials.0c01434