innoVation Series – Research Article of the Month – December

This article from Cui et al., 2019 underlines once again how important mature human iPSC-derived cardiomyocytes (hiPSC-CMs) are for investigating tox effects reliably for human cancer treatment.

Knowing that children are more susceptible to reveal doxorubicin-induced cardiotoxicity, this article investigates underlying mechanisms by comparing hiPSC-CMs of 30 and 60 days in culture that were treated with doxorubicin and dexrazoxane – the recognized cardioprotective drug for treating DOX‐induced cardiotoxicity.

The results show that immature cardiomyocytes (30 days in culture) are more sensitive to DOX as a result of a higher concentration of topoisomerase IIα, which leads to more DNA damage.

Find the article here


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