The article from Chirikian et al., 2022 covering April and May of the innoVation Series addresses the effects of xeno-free cryopreservation on the contractile properties of human iPSC-derived cardiomyocytes.
Read the article to find out about alterations in both the contractile and calcium handling properties of xeno-free cryopreserved hiPSC-CMs. Collectively, the authors observed increased force production, enhanced contractile dynamics, and delayed calcium transients in cryopreserved hiPSC-CMs. Additionally, they observed larger hiPSCs-CMs after xeno-free cryopreservation which coincided with higher functional fitness also consistent with the upregulation of genes SERCA2A and RYR2.
Find the article here