innoVation Series April – May 2022

The article from Chirikian et al., 2022 covering April and May of the innoVation Series addresses the effects of xeno-free cryopreservation on the contractile properties of human iPSC-derived cardiomyocytes.

Read the article to find out about alterations in both the contractile and calcium handling properties of xeno-free cryopreserved hiPSC-CMs. Collectively, the authors observed increased force production, enhanced contractile dynamics, and delayed calcium transients in cryopreserved hiPSC-CMs. Additionally, they observed larger hiPSCs-CMs after xeno-free cryopreservation which coincided with higher functional fitness also consistent with the upregulation of genes SERCA2A and RYR2.

Find the article here


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