With the New Year we are focussing on the importance of human iPSC-derived cardiomyocyte beat rate pacing for the analysis of drug effects.
Hinata et al., 2022 investigated the relationship between contraction parameters and beating rates of cardiac cell sheet tissues by directly measuring the contraction force and compared the effects of ion channel drugs (mexiletine, ranolazine, and dofetilide) on contraction parameters under spontaneous beating conditions with those under pacing (1 Hz) conditions.
Find the full article here
