innoVation Facts – Cardiac Maturation Cues (Part 2)

In our second part of the innoVation Facts series addressing cardiac maturation cues, we focus on phenotypic changes that take place when human iPSC-cardiomyocytes (hiPSC-CMs) are cultured on FLEXcyte 96 plates to emulate the physiological conditions of the human heart. To visualize changes in actin filament development, staining with Phalloidin was performed on Cardiosight-s (Nexel…Continue readinginnoVation Facts – Cardiac Maturation Cues (Part 2)

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innoVation Series – Research Article of the Month – December

This article from Cui et al., 2019 underlines once again how important mature human iPSC-derived cardiomyocytes (hiPSC-CMs) are for investigating tox effects reliably for human cancer treatment. Knowing that children are more susceptible to reveal doxorubicin-induced cardiotoxicity, this article investigates underlying mechanisms by comparing hiPSC-CMs of 30 and 60 days in culture that were treated…Continue readinginnoVation Series – Research Article of the Month – December

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innoVation Facts – Cardiac Maturation Cues (Part 1)

We are happy to announce our new innovation facts blog focussing on news about the FLEXcyte technology and related topics! We start the blog with a series about cardiac maturation cues, a hot topic for everyone working on human iPSC-derived cardiomyocytes. In this first part, we show you how to use the physiological environment of…Continue readinginnoVation Facts – Cardiac Maturation Cues (Part 1)

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innoVation Series – Research Article of the Month – October

This months research article caught our eye because it analyzes the cell persistance and electrical integration of intramyocardially transplanted murine iPSC-derived cardiomyocytes. Murine iPSC-derived cardiomyocytes were tested in vitro for best attachment rates at three different developmental stages. The best two were then selected for injection into infarcted hearts of adult mice. Cell persistance and…Continue readinginnoVation Series – Research Article of the Month – October

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Safety Pharmacology Society Meeting, October 04 – 08, 2021

Meet us at our booth at the Safety Pharmacology Society Meeting held virtually this year! We will also present a poster (#75) entitelt Physiological Versus Unphysiological Cell Culture Conditions: How The Environment Alters Gene Expression, Phenotype and Functional Properties of Human iPSC-Derived Cardiomyocytes as part of the rapid-fire presentations on Thursday, October 7th, 11:25 AM…Continue readingSafety Pharmacology Society Meeting, October 04 – 08, 2021

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Eurotox Meeting, September 26 – October 01, 2021

Join us at the virtual Eurotox annual meeting and come to our poster entitelt P23-30 High Throughput Chronic Cardiotoxicity Evaluation of Human iPSC-Derived Cardiomyocytes in a Pro Maturation Environment! We are looking forward to talking to you about the FLEXcyte 96 and its use for chronic cardiotox evaluation. Go to the conference website hereContinue readingEurotox Meeting, September 26 – October 01, 2021

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Nanion Technologies Usermeeting, September 29 – 30, 2021

Come and join us at Nanion Technologies Hybrid Usermeeting held virtually AND in person in Munich! Register hereContinue readingNanion Technologies Usermeeting, September 29 – 30, 2021

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innoVation Series – Research Article of the Month – July 2021

July’s innovation Series article by Luo and Li et al., 2020 focuses on the role of type 2 ryanodine receptor (RYR2), an essential calcium channel required for excitation-contraction coupling in cardiomyocytes during human embryonic cardiac development. Read the article to find out how human iPSC-cardiomyocyte RYR2 -/- lines were generated via CRISP/Cas9 and compared to…Continue readinginnoVation Series – Research Article of the Month – July 2021

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innoVation Series – Research Article of the Month – June 2021

Similar to April’s innovation series issue, we have chosen an article that deals with the question of whether a cardiotoxic effect is of direct or systemic origin. In this month’s issue we are not looking at CAR-T related cardiac toxicity, but SARS-CoV-2 related severe cardiovascular symptoms. Read the article by Marchiano et al., 2021 and…Continue readinginnoVation Series – Research Article of the Month – June 2021

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11th World Congress on Alternatives and Animal Use in Life Sciences 23rd of August – 2nd of September, 2021

Meet us at the 11th World Congress on Alternatives and Animal use in Life Sciences this year. Detailed information about Posters will follow.Continue reading11th World Congress on Alternatives and Animal Use in Life Sciences 23rd of August – 2nd of September, 2021

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