innoVitroJuly’s innovation Series article by Luo and Li et al., 2020 focuses on the role of type 2 ryanodine receptor (RYR2), an essential calcium channel required for excitation-contraction coupling in cardiomyocytes during human embryonic cardiac development. Read the article to find out how human iPSC-cardiomyocyte RYR2 -/- lines were generated via CRISP/Cas9 and compared to…Continue readinginnoVation Series – Research Article of the Month – July 2021
Similar to April’s innovation series issue, we have chosen an article that deals with the question of whether a cardiotoxic effect is of direct or systemic origin. In this month’s issue we are not looking at CAR-T related cardiac toxicity, but SARS-CoV-2 related severe cardiovascular symptoms. Read the article by Marchiano et al., 2021 and…Continue readinginnoVation Series – Research Article of the Month – June 2021
Meet us at the 11th World Congress on Alternatives and Animal use in Life Sciences this year. Detailed information about Posters will follow.Continue reading11th World Congress on Alternatives and Animal Use in Life Sciences 23rd of August – 2nd of September, 2021
Meet us virtuall at the 3rd European Organ-On-A-Chip Society annual meeting this year! More details will come soon.Continue readingEuropean Organ-On-A-Chip Society (EUROoCS), 1st -2nd July, 2021
We keep the focus on reviews this month, with one that has summarized current maturation methods for human induced pluripotent stem cell-derived cardiomyocytes. Read the review to learn about maturity evaluation of human iPSC-derived cardiomyocytes in comparison to adult cardiomyocytes and how prolonged culture time, biochemical cues, cellular interaction, 3D cell-culture, and of course substrate…Continue readinginnoVation Series – Research Article of the Month – May 2021
This months article is an intersting review that summarizes the current understanding of potential cardiovascular toxicities of CD19-specific Car T cell therapies. CD19-specific chimeric antigen receptor (CAR) T cell therapies have shown remarkable early success in highly refractory and relapsing hematological malignancies. However, most significant side effects of the therapy are cytokine release syndrome (CRS)…Continue readinginnoVation Series – Research Article of the Month – April 2021
Our partner Nanion Technologies will present this upcoming Cardiac Safety Symposium with keynote speakers of the saftey pharmacological field including our Scientific Communications Manager Bettina Lickiss, who will present cardiac contractility assessment data with integrated optical and mechanical stimulation of human iPSC-derived cardiomyocytes. Register here Check out the FLEXcyte technology hereContinue readingCardiac Safety Symposium May 19 – 20, 2021
This month’s innovation series research article was published from our colleagues at the University of Cologne last week. Find out how you can optimize cardiac differentiation out of human induced pluripotent stem cells. This biomimetic approach is based on poly(dimethylsiloxane) (PDMS) substrates with similar stiffness to the native heart and a well-defined surface chemistry obtained…Continue readinginnoVation Series – Research Article of the Month – March 2021
Come and meet us virtually at this years Society of Toxicology (SOT) Conference!Continue readingMarch 12 – 26, 2021
Connect with us at the ELRIG Research and Innovation Conference held virtually!Continue readingFebruary 23-24, 2021
