innoVitroThe last part of our innoVation Facts series dealing with cardiac maturation cues focused on gene expression analysis of human iPSC-derived cardiomyocytes (hiPSC-CMs) cultured either on physiological FLEXcyte or regular cell culture plates. The data shows increased expression levels of ACTC1 and ACTN2 genes (both producing cytoskeleton-related proteins) as well as the MYH7 gene (important…Continue readinginnoVation Facts – Cardiac Maturation Cues (Part 3)
We start the new year with an article by Lebrec et al., 2021 covering CAR-T / TCR immunotherapy research findings with a focus on nonclinical safety evaluation. Engineered T cell therapies provide huge opportunities to address current unmet medical needs but present also unique challenges in terms of safety assessment during nonclinical and clinical development.…Continue readinginnoVation Series – Research Article of the Month – January
Meet us at the 66th Biophysical Society Meeting at the Moscone Center in San Francisco, California, USA. We will present new data on how to fascilitate cardiac maturation cues of human iPSC-derived cardiomyocytes for in vitro cardiac risk evaluation at Nanion Technologies exhibitor symposium taking place on Monday, 21st of February, 2022.Continue readingBiophysical Society 66th Annual Meeting, February 19 -23, 2022
In our second part of the innoVation Facts series addressing cardiac maturation cues, we focus on phenotypic changes that take place when human iPSC-cardiomyocytes (hiPSC-CMs) are cultured on FLEXcyte 96 plates to emulate the physiological conditions of the human heart. To visualize changes in actin filament development, staining with Phalloidin was performed on Cardiosight-s (Nexel…Continue readinginnoVation Facts – Cardiac Maturation Cues (Part 2)
This article from Cui et al., 2019 underlines once again how important mature human iPSC-derived cardiomyocytes (hiPSC-CMs) are for investigating tox effects reliably for human cancer treatment. Knowing that children are more susceptible to reveal doxorubicin-induced cardiotoxicity, this article investigates underlying mechanisms by comparing hiPSC-CMs of 30 and 60 days in culture that were treated…Continue readinginnoVation Series – Research Article of the Month – December
We are happy to announce our new innovation facts blog focussing on news about the FLEXcyte technology and related topics! We start the blog with a series about cardiac maturation cues, a hot topic for everyone working on human iPSC-derived cardiomyocytes. In this first part, we show you how to use the physiological environment of…Continue readinginnoVation Facts – Cardiac Maturation Cues (Part 1)
This months research article caught our eye because it analyzes the cell persistance and electrical integration of intramyocardially transplanted murine iPSC-derived cardiomyocytes. Murine iPSC-derived cardiomyocytes were tested in vitro for best attachment rates at three different developmental stages. The best two were then selected for injection into infarcted hearts of adult mice. Cell persistance and…Continue readinginnoVation Series – Research Article of the Month – October
Meet us at our booth at the Safety Pharmacology Society Meeting held virtually this year! We will also present a poster (#75) entitelt Physiological Versus Unphysiological Cell Culture Conditions: How The Environment Alters Gene Expression, Phenotype and Functional Properties of Human iPSC-Derived Cardiomyocytes as part of the rapid-fire presentations on Thursday, October 7th, 11:25 AM…Continue readingSafety Pharmacology Society Meeting, October 04 – 08, 2021
Join us at the virtual Eurotox annual meeting and come to our poster entitelt P23-30 High Throughput Chronic Cardiotoxicity Evaluation of Human iPSC-Derived Cardiomyocytes in a Pro Maturation Environment! We are looking forward to talking to you about the FLEXcyte 96 and its use for chronic cardiotox evaluation. Go to the conference website hereContinue readingEurotox Meeting, September 26 – October 01, 2021
Come and join us at Nanion Technologies Hybrid Usermeeting held virtually AND in person in Munich! Register hereContinue readingNanion Technologies Usermeeting, September 29 – 30, 2021
