innoVitroThis months research article caught our eye because it analyzes the cell persistance and electrical integration of intramyocardially transplanted murine iPSC-derived cardiomyocytes. Murine iPSC-derived cardiomyocytes were tested in vitro for best attachment rates at three different developmental stages. The best two were then selected for injection into infarcted hearts of adult mice. Cell persistance and…Continue readinginnoVation Series – Research Article of the Month – October
Meet us at our booth at the Safety Pharmacology Society Meeting held virtually this year! We will also present a poster (#75) entitelt Physiological Versus Unphysiological Cell Culture Conditions: How The Environment Alters Gene Expression, Phenotype and Functional Properties of Human iPSC-Derived Cardiomyocytes as part of the rapid-fire presentations on Thursday, October 7th, 11:25 AM…Continue readingSafety Pharmacology Society Meeting, October 04 – 08, 2021
Join us at the virtual Eurotox annual meeting and come to our poster entitelt P23-30 High Throughput Chronic Cardiotoxicity Evaluation of Human iPSC-Derived Cardiomyocytes in a Pro Maturation Environment! We are looking forward to talking to you about the FLEXcyte 96 and its use for chronic cardiotox evaluation. Go to the conference website hereContinue readingEurotox Meeting, September 26 – October 01, 2021
Come and join us at Nanion Technologies Hybrid Usermeeting held virtually AND in person in Munich! Register hereContinue readingNanion Technologies Usermeeting, September 29 – 30, 2021
July’s innovation Series article by Luo and Li et al., 2020 focuses on the role of type 2 ryanodine receptor (RYR2), an essential calcium channel required for excitation-contraction coupling in cardiomyocytes during human embryonic cardiac development. Read the article to find out how human iPSC-cardiomyocyte RYR2 -/- lines were generated via CRISP/Cas9 and compared to…Continue readinginnoVation Series – Research Article of the Month – July 2021
Similar to April’s innovation series issue, we have chosen an article that deals with the question of whether a cardiotoxic effect is of direct or systemic origin. In this month’s issue we are not looking at CAR-T related cardiac toxicity, but SARS-CoV-2 related severe cardiovascular symptoms. Read the article by Marchiano et al., 2021 and…Continue readinginnoVation Series – Research Article of the Month – June 2021
Meet us at the 11th World Congress on Alternatives and Animal use in Life Sciences this year. Detailed information about Posters will follow.Continue reading11th World Congress on Alternatives and Animal Use in Life Sciences 23rd of August – 2nd of September, 2021
Meet us virtuall at the 3rd European Organ-On-A-Chip Society annual meeting this year! More details will come soon.Continue readingEuropean Organ-On-A-Chip Society (EUROoCS), 1st -2nd July, 2021
We keep the focus on reviews this month, with one that has summarized current maturation methods for human induced pluripotent stem cell-derived cardiomyocytes. Read the review to learn about maturity evaluation of human iPSC-derived cardiomyocytes in comparison to adult cardiomyocytes and how prolonged culture time, biochemical cues, cellular interaction, 3D cell-culture, and of course substrate…Continue readinginnoVation Series – Research Article of the Month – May 2021
This months article is an intersting review that summarizes the current understanding of potential cardiovascular toxicities of CD19-specific Car T cell therapies. CD19-specific chimeric antigen receptor (CAR) T cell therapies have shown remarkable early success in highly refractory and relapsing hematological malignancies. However, most significant side effects of the therapy are cytokine release syndrome (CRS)…Continue readinginnoVation Series – Research Article of the Month – April 2021
