innoVitroJuly’s innovation Series article by Luo and Li et al., 2020 focuses on the role of type 2 ryanodine receptor (RYR2), an essential calcium channel required for excitation-contraction coupling in cardiomyocytes during human embryonic cardiac development. Read the article to find out how human iPSC-cardiomyocyte RYR2 -/- lines were generated via CRISP/Cas9 and compared to…Continue readinginnoVation Series – Research Article of the Month – July 2021
Similar to April’s innovation series issue, we have chosen an article that deals with the question of whether a cardiotoxic effect is of direct or systemic origin. In this month’s issue we are not looking at CAR-T related cardiac toxicity, but SARS-CoV-2 related severe cardiovascular symptoms. Read the article by Marchiano et al., 2021 and…Continue readinginnoVation Series – Research Article of the Month – June 2021
We keep the focus on reviews this month, with one that has summarized current maturation methods for human induced pluripotent stem cell-derived cardiomyocytes. Read the review to learn about maturity evaluation of human iPSC-derived cardiomyocytes in comparison to adult cardiomyocytes and how prolonged culture time, biochemical cues, cellular interaction, 3D cell-culture, and of course substrate…Continue readinginnoVation Series – Research Article of the Month – May 2021
This months article is an intersting review that summarizes the current understanding of potential cardiovascular toxicities of CD19-specific Car T cell therapies. CD19-specific chimeric antigen receptor (CAR) T cell therapies have shown remarkable early success in highly refractory and relapsing hematological malignancies. However, most significant side effects of the therapy are cytokine release syndrome (CRS)…Continue readinginnoVation Series – Research Article of the Month – April 2021
This month’s innovation series research article was published from our colleagues at the University of Cologne last week. Find out how you can optimize cardiac differentiation out of human induced pluripotent stem cells. This biomimetic approach is based on poly(dimethylsiloxane) (PDMS) substrates with similar stiffness to the native heart and a well-defined surface chemistry obtained…Continue readinginnoVation Series – Research Article of the Month – March 2021
This month’s innovation series article deals with how to “sense” magnetic fields. Ikeya & Woodward demonstrate that flavin-based autofluorescence in native, untreated HeLa cells is magnetic field sensitive, due to the formation and electron spin–selective recombination of spin-correlated radical pairs. The radical pair mechanism is the favored hypothesis for explaining biological effects of weak magnetic…Continue readinginnoVation Series – Research Article of the Month – February 2021
The publication of Heiko Lemcke et al., 2020 made it to our very first “innovation series” research article of the month, due to it’s focus on a very interesting and different approach to evaluate iPSC cardiomyocyte maturation! Learn more about how you can use a super resolution-based approach to quantitatively evaluate the structural maturation of…Continue readinginnoVation Series – Research Article of the Month – January 2021
